2. Signaling Pathways
  3. GPCR/G Protein
  4. LPL Receptor

LPL Receptor

Lysophospholipid Receptor

LPL Receptor

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LPL Receptor (Lysophospholipid Receptor) group are members of the G protein-coupled receptor family of integral membrane proteins that are important for lipid signaling. In humans, there are eight LPL receptors, each encoded by a separate gene. These LPL receptor genes are also sometimes referred to as "Edg". LPL receptor ligands bind to and activate their cognate receptors located in the cell membrane. Depending on which ligand, receptor, and cell type is involved, the activated receptor can have a range of effects on the cell. These include primary effects of inhibition of adenylyl cyclase and release of calcium from the endoplasmic reticulum, as well as secondary effects of preventingapoptosis and increasing cell proliferation. Type: LPAR1, LPAR2, LPAR3, LPAR4, LPAR5, LPAR6, S1PR1, S1PR2, S1PR3, S1PR4, S1PR5.

LPL Receptor Isoform Specific Products:

LPL Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-149210
    S1PR1 ligand 1
    S1PR1 ligand 1 (compound 6 h) is a specific S1PR1 ligand with IC50 = 8.7 nM. S1PR1 ligand 1 has good brain uptake. S1PR1 ligand 1 can be labeled with 18F to study the function of S1PR1 in brain diseases.
    S1PR1 ligand 1
  • HY-50692
    CAY10734
    		Agonist
    CAY10734 is the agonist for sphingosine-1-phosphate receptor 1 (S1P1) with an IC50 of 1.3 nM. CAY10734 promotes the recirculation of peripheral blood lymphocytes, and is a potential immunosuppressant.
    CAY10734
  • HY-12789R
    Etrasimod (Standard)
    		Antagonist
    Etrasimod (Standard) is the analytical standard of Etrasimod. This product is intended for research and analytical applications. Etrasimod (APD334) is a potent, selective and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor with an IC50 value of 1.88 nM in CHO cells.
    Etrasimod (Standard)
  • HY-107615R
    TC LPA5 4 (Standard)
    		Antagonist
    TC LPA5 4 (Standard) is the analytical standard of TC LPA5 4 (HY-107615). This product is intended for research and analytical applications. TC LPA5 4 is a LPA5 (GPR92)-specific non-lipid antagonist. TC LPA5 4 inhibits LPA-induced aggregation of isolated human platelet (LPA5-RH7777 cell line) with an IC50 of 800 nM. TC LPA5 4 displays selectivity for LPA5 over 80 other screened agent targets. TC LPA5 4 inhibits cell proliferation and migration of thyroid cancer cells.
    TC LPA5 4 (Standard)
  • HY-108495R
    CYM50308 (Standard)
    		Agonist
    CYM50308 (Standard) is the analytical standard of CYM50308 (HY-108495). This product is intended for research and analytical applications. CYM50308 (ML248) is a potent, selective and high affinity sphingosine-1-phosphate receptor 4 (S1P4-R) agonist with an EC50 of 56 nM. CYM50308 displays 37-fold more selective for S1P4-R than S1P5-R. CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes at concentrations up to 25 μM.
    CYM50308 (Standard)
  • HY-182618
    XAX-162
    		Agonist
    XAX-162 is a highly selective sphingosine 1-phosphate receptor 2 (S1PR2) agonist with a human EC50 of 0.55 μM. XAX-162 does not activate other S1P receptors. XAX-162 exhibits noncompetitive inhibition of activity by S1PR2 antagonist JTE-013 (HY-100675).
    XAX-162
  • HY-N16096
    VPC 01091
    		Antagonist
    VPC 01091 is a S1PR3 antagonist.
    VPC 01091
  • HY-120282
    ONO-9910539
    		Antagonist
    ONO-9910539 is a lysophosphatidic acid receptor 1 (LPAR1) antagonist. ONO-9910539 is applicable to the research of idiopathic pulmonary fibrosis.
    ONO-9910539
  • HY-12616
    ACT-209905
    		Agonist
    ACT-209905 is a S1P1 receptor agonist. ACT-209905 can inhibit glioblastoma (GBM) cell growth and migration. ACT-209905 also has immunomodulating activity, and can be used in research of autoimmune diseases.
    ACT-209905
  • HY-W008947R
    SEW​2871 (Standard)
    		Agonist
    SEW2871 is an orally active, potent, highly selective S1P1 (sphingosine-1-phosphate type 1 receptor) agonist, with an EC50 of 13.8 nM. SEW2871 activates ERK, Akt, and Rac signaling pathways and induces S1P1 internalization and recycling. SEW2871 reduces lymphocyte numbers in blood. SEW2871 can be used for the research of diabetes, Alzheimer’s disease, liver fibrosis, and inflammatory responses.
    SEW​2871 (Standard)
  • HY-18334
    GSK-2262167 sodium
    		Agonist
    GSK-2262167 sodium is a selective S1P1 receptor agonist. GSK-2262167 sodium is used for research on inflammatory and immune diseases.
    GSK-2262167 sodium
  • HY-119221
    AUY954
    		Agonist
    AUY954 is an oral active and selective sphingosine-1-phosphate receptor 1 agonist with the EC50 values of 1.2 nM, 0.9 nM >10,000 nM, 1,210 nM, >1,000 nM, and 340 nM for hS1P2, mS1P2, S1P2, S1P3, S1P4, and S1P5 receptors, respectively. AUY954 can be used for study of experimental autoimmune neuritis.
    AUY954
  • HY-120633A
    BMS-986104 hydrochloride
    		Agonist
    BMS-986104 hydrochloride is a selective S1P1 receptor partial agonist, and can be used for research of autoimmune diseases.
    BMS-986104 hydrochloride
  • HY-139133
    L-NASPA
    		Inhibitor
    L-NASPA is a ophosphatidic acid (LPA) inhibitor useful in the study of platelet activation.
    L-NASPA
  • HY-108490R
    VPC 23019 (Standard)
    		Modulator
    VPC 23019 (Standard) is the analytical standard of VPC 23019 (HY-108490). This product is intended for research and analytical applications. VPC 23019, an aryl amide-containing Sphingosine 1-phosphate (S1P) analog, is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively) and an agonist at the S1P4 and S1P5 receptors (pEC50= 6.58 and 7.07, respectively).
    VPC 23019 (Standard)
  • HY-U00366
    S1PR1-MO-1
    		Modulator
    S1PR-MO-1 is the modulator of sphingosine-1-phosphate receptor, used for research of hyperproliferative, inflammatory diseases.
    S1PR1-MO-1
Cat. No. Product Name / Synonyms Application Reactivity
LPL Receptor Isoform Comparison

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